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Computational Biology Research Center(CBRC)
We developed an automated system for discovering seven transmembrane helix receptors (7-TMR) in the whole human genome sequences using algorithms of gene finding, sequence search, motif and domain assignment, transmembrane helix prediction and the gene quality refinement. This system is intended to detect sequences of multi-exon or remote homologues that can not be detected by using conventional sequence search tools alone. With the careful assessment of the analyzing components, we obtained candidate datasets, with several predicting accuracy, among which we found at least 1,033 and at most 1,916 candidate 7-TMR genes from human genome.
- Makiko Suwa,Toshiyuki Sato,Ikuo Okouchi,Toshitaka Kumagai,Motonori Arita,Kiyoshi Asai and Yutaka Akiyama
- Computational Biology Research Center (CBRC),National Institute of Advanced Industrial Science and Technology (AIST),2-41-6 Aomi, Koutou-ku, Tokyo 135-0064, JAPAN.
- Shinichi Matsumoto,Shuichi Tsutsumi,Hiroyuki Aburatani
- Genome Science Division, RCAST, Univ. Tokyo, 4-6-1 Komaba,Meguro-ku, Tokyo 153-8904, JAPAN.
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Recent Revise on 2003/10/09.